Infrastructures proliferate within mental health. Services are developed and instantiated both through and as particular socio-material configurations. These are underpinned by diverse kinds of infrastructure, as well as serving as the underpinning for therapeutic encounters. The knowledge drawn upon, ignored or un-encountered by psychological therapists is itself produced through a range of infrastructural arrangements, which are impacted and directed by research funders in varying ways. In this talk, I take considerations of infrastructure as a departure point for discussing two Wellcome Trust-funded projects on the sociology of mental health. The first represents an analysis of the social dimensions of initiatives to enhance access to psychological therapy in England and Scotland; the second is a new study interrogating innovation in psychiatric diagnosis across the US and the UK. I will discuss the forms of normativity that (are claimed to) structure both of the cases I explore, and consider the infrastructural arrangements my respondents imagine and enact in response to these. In turn, I want to reflect on what (drives to develop) infrastructures do to the ontologies of pathologies, patients and professionals working in mental health research and practice.